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The second stage involves coupling pesticide metabolites to sugars, amino acids, or glutathione by glutathione-S-transferase (GST) and uridine diphosphate UDP-glycosyltransferase (UGT), which is less toxic and more soluble in water
Pentoxifylline (PTX), a non-specific phosphodiesterase inhibitor, has emerged as a promising adjunct therapy for chronic kidney disease (CKD) due to its multifaceted mechanisms of action
However, in disease states, this interaction may turn maladaptive, promoting inflammation and neurodegeneration
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