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[2] [3] [4] The purpose of phase I is to introduce polar groups that either themselves directly facilitate excretion or to create reactive functional groups

much of it is broken down before it can meaningfully raise intracellular antioxidant levels

Subsequent cell culture studies revealed that GSSG accumulation, as opposed to GSH reduction, sensitized hepatocytes to TNF killing by reducing the TNF-triggered NF-B activity

[167] Carlsson was awarded the 2000 Nobel Prize in Physiology or Medicine for showing that dopamine is not only a precursor of norepinephrine (noradrenaline) and epinephrine (adrenaline), but is also itself a neurotransmitter