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Cyanocobalamin Drugs (BNF/NICE)
A significant percentage of the ME/CFS population possesses mutations in the MTHFR (methylenetetrahydrofolate reductase) gene
Dosing principles remain similar (5002500 mcg range), but the choline and inositol components support mitochondrial energy and metabolism, which some providers use to guide slightly different frequency protocols
Arthur Heller, HealthTap There is also the risk of bacterial contamination, which increases as the B12 ages
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