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J Clin Invest (1961) 40:12809

12 mg target dose (TRIUMPH-1, TRIUMPH-2, TRIUMPH-4) 9 mg target dose (TRIUMPH-1, TRIUMPH-2, TRIUMPH-4) 4 mg target dose (TRIUMPH-1, TRIUMPH-2 only) What changed from Phase 2 to Phase 3 The key differences in the Phase 3 titration schedule: 6 mg intermediate step added

Mcl-1/CDK9Targeting by AZD5991/AZD4573 Overcomes Intrinsic and Acquired Venetoclax Resistance in vitro and in vivo in PDX Model of AML through Modulation of Cell Death and Metabolic Functions