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In SOUL, composite HF endpoints were analysed as a secondary outcome, with oral semaglutide resulting in a non-significant reduction in HF events
Beyond its antioxidant role, Glutathione is central to Phase II hepatic detoxification research, where it acts as a conjugate for electrophilic xenobiotics and reactive metabolites via glutathione S-transferase (GST) enzymes, facilitating their excretion
If additional glycaemic control is needed after at least 4 weeks, the dose may be increased to 1 mg or 2 mg weekly, as clinically indicated
Patients with specific FTO rs9939609 genotypes, for example, may see accelerated early weight loss but require careful dose titration, while others with favorable GLP1R rs6923761 variants may achieve results at lower unit amounts
