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The compound was designed based on Epithalamin, a natural peptide fraction extracted from bovine pineal gland tissue

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1 Introduction Cancer is still regarded as one of the topmost life-threatening disorders in the world, and conventional therapeutic approaches chemotherapy, radiotherapy, immunotherapy are limited by marked toxicity, resistance and relapse rates ( in vitro and in vivo research on the ability of honey to influence tumor growth, metastatic behavior, and chemosensitization, as well as clinical studies focusing on its role in the treatment-related toxicity

The link between GSTP and cancer is most obvious in the overexpression of GSTP in many cancers, but it is also supported by the fact that the transformed phenotype of tumor cells is associated with aberrantly regulated kinase signaling pathways and cellular addiction to overexpressed proteins