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Discontinuation due to factors typically irrelevant in clinical trial settings (i.e., cost or insurance-related issues and medication shortages) could contribute to the substantial discrepancy between discontinuation rates in pivotal phase 3 trials and those reported in real-world studies. Regarding discontinuation due to side effects, Gasoyan says we do not currently know of patient-level predictors that would help identify who might experience side effects and why
37-study meta-analysis, 3,048 patients)
However, the high cost of semaglutide without insurance can pose a barrier to access for many individuals
Experiments with varying substrate concentrations revealed MichaelisMenten type kinetics with a V max of 48.1 1.4 mol min 1 mg 1 and a K m of 2.6 0.14 mM MSA (Figure 5C)
