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When Cannabis May Be a Poor Fit Extra caution or avoidance may be appropriate when the patient has active delirium, severe orthostatic symptoms, repeated falls, uncontrolled psychosis, a prior severe cannabinoid reaction, major interaction risk, unreliable product composition, unsafe administration, or a goal of preserving maximum alertness that THC repeatedly undermines

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The same principle applies when converting from semaglutide to tirzepatide or when transitioning between compounded and brand-name formulations