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Tirzepatide causes nausea in slightly higher numbers of patients initially because its GIP+GLP-1 dual action is more potent, but the difference is modest and nausea typically resolves within 4-8 weeks
The FDA prescribing information does not list hepatotoxicity as a known adverse effect, and extensive clinical trial data have not identified significant liver-related safety signals
It receives a large part of the blood from the intestine via the portal vein, which puts it on the front line against nutrients
Intern Med 103 , 412 (2022)
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