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The MC1R activity still drives pigmentation, but the added MC4R activity is what produces the erectile/libido effects and the appetite suppression and nausea that Melanotan 2 is notorious for effects a MC1R-preferential molecule like Melanotan 1 does not share
What the trials showed In the phase 2 trial, injection site reactions with cagrilintide occurred at dramatically higher rates than placebo
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