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The full therapeutic effect may take 16-20 weeks to manifest, particularly with the Wegovy titration schedule
So, do what you can to get at least 79 hours of sleep per night
For example, a three-month course of lactulose therapy significantly improved sleep quality, reduced daytime sleepiness, and increased sleep duration and REM sleep in patients with minimal HE (39)
It can be mitigated by avoiding alcohol, smoking, spicy foods, eating late at night and identifying triggers by keeping a food diary
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