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Description

GSH conjugation occurs by one of the two mechanisms: 1

After 12 weeks treatment, the reductions in HbA1c from baseline were 0.96% with 1.8mg MAR709, 0.9% with 1mg tirzepatide and 1.7% with 5mg tirzepatide

The cysteine moiety of GSH can be liberated via -glutamyl cycle in which exported GSH is cleaved sequentially by two exofacial enzymes, namely -glutamyl transpeptidase (GGT) and dipeptidase (DP) to release cysteine which is then imported into the cells 6