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Nuclear mitochondrial gene abnormalities were ruled-out using an oligonucleotide array with comparative genomic hybridization analysis that examines 180 nuclear genes involved in mitochondria function, including genes involved in fatty-acid oxidation, carnitine metabolism, mitochondrial biogenesis, mtDNA maintenance, transcription and translation, and ETC complex assembly (MitoMet, Baylor Medical Genetics Laboratory)

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