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Levels decline with age and drop further in chronic disease, including Parkinson's disease, liver disease, heart disease, and alcohol use disorder
Critical role for NAD glycohydrolase in regulation of erythropoiesis by hematopoietic stem cells through control of intracellular NAD content
Overall, increased oxygen consumption, energy production, and lactic acid production during high-intensity exercise can increase free radicals and oxidative stress, which can cause damage to cells and tissues if not adequately neutralized by the bodys antioxidant defense system
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