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The 12 mg row is included for completeness because the Phase 2 trial escalated through 1 mg, 2 mg, 4 mg, 8 mg and 12 mg arms, with the 12 mg cohort reaching approximately 24.2% mean weight loss at 48 weeks at the cost of a heavier nausea and constipation burden [2][5]
49 JonesBBuenaventuraTKandaNChabosseauPOwenBMScottRet al
Reduced estrogen also causes a fat redistribution to the abdomen in the form of visceral fat, which is linked to increased risk of insulin resistance and other metabolic diseases
For instance, some providers may shorten titration intervals to meet patient expectations
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