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Further evidence for this notion comes from observations that Prx5 downregulation correlates with downregulation of molecular chaperones, and upregulation of proteins associated with neuroinflammation (Knoops et al., 2016)
Fernndez-Checa, Liver Unit, Hospital Clnic, Centre Esther Koplowitz, Institut dInvestigacions Biomdiques August Pi i Sunyer (IDIBAPS)Centro de Investigacin Biomdica en Red de Enfermedades Hepticas y Digestivas (CIBERehd), Planta Cuarta, C/Rossell 149, Barcelona 08036, Spain e-mail: [email protected] This article was submitted to Experimental Pharmacology and Drug Discovery, a Section of the journal Frontiers in Pharmacology
The trial period was 12 weeks and the dose was 60 mg/kg/day in three doses with a maximum of 4,200 mg/day
To understand the underlying molecular mechanisms, the expression levels of 3-AR mRNA in both white and brown adipose tissue were assessed using reverse transcription followed by PCR and Southern blotting
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