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Macromolecular drug-encapsulating NPs can be more efficiently delivered into the AD brain harnessing the AMT mechanism via their surface conjugation with cationic oligos, proteins or basic cell-penetrating peptides for an electrostatic interaction with the negative charged surfaces of the capillary endothelial cells (Lu, 2012
A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis
Injecting there increases the risk of hitting a blood vessel, which causes bruising, or irritating a nerve, which causes sharp pain that radiates down the leg
Starting at a low dose and increasing gradually helps minimize these effects
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